一、PI简介

1593654979203045645.jpg魏林mg游戏平台电子手机版下载教授、博士生导师,河北省省管优秀专家。河北省重大疾病免疫机制及干预重点实验室主任

教育经历:

1978/07-1983/07    mg游戏平台电子手机版下载医学系,学士

1986/07-1989/07    mg游戏平台电子手机版下载微免教研室,硕士

1997/07-2000/07    第二军医大学医学遗传学,博士

2002/07-2004/07  美国University of Kansas Medical Center, 博士后

2010/10-2011/05  美国St.Louis大学高级访问学者

学术机构任职: 

中国免疫学会常务理事、河北省免疫学会理事长中华医学会微生物学与免疫学分会常务委员。

 

 

二、研究方向:

主要从事病毒与宿主相互作用、慢性炎症微环境对巨噬细胞极化及其介导的微生物免疫逃逸的分子机制等研究。

 

 

三、代表性论文

1

Jiachao Wang#, Meiqi Meng#, Miao Li, Xiaofei Guan, Jianguo Liu, Xue Gao, Qingqing Sun, Jinquan Li, Cuiqing Ma*, Lin Wei*,. Integrinα5β1, as a Receptor of Fibronectin, Binds the FbaA Protein of Group A Streptococcus To Initiate Autophagy during Infection  mBio 2020 Volume 11 Issue 3 e00771-20

2

Jian Li#Miao Li#, Xiuli Wang, Mengfei Sun, Cuiqing Ma, Wenzhang LiangXue Gao, Lin Wei*. LncRNA NRAV promotes respiratory syncytial virus (RSV) replication by regulating vesicle transportation via targeting miR-509-3p/Rab5ca xis J.Virol. 2020, doi:10.1128/JVI.00113-20

3

Cuiqing Ma#, Xue Gao#, Shuhui Wu, Ling Zhang, Jiachao Wang, Zhengzheng Zhang, Zhiyan Yao, Xiaotian Song, Wenjian Li, Xiurong Wang, Huidong Feng, Lin Wei*. M Protein of Group A Streptococcus Plays an Essential Role in Inducing High Expression of A20 in Macrophages Resulting in the Downregulation of Inflammatory Response in Lung Tissue. Front  Cell  Infect Mi. 2018.8(131): 1-13

4

Miao Li#, Jian Li#, Ruihong Zeng,Jianling YangJianguo LiuZhengzheng Zhang, Xiaotian Song, Zhiyan YaoCuiqing MaWenjian LiKai WangLin Wei* Respiratory Syncytial Virus Replication Is Promoted by Autophagy-Mediated Inhibition of Apoptosis. J Virol. 2018 Apr 15; 92(8): e02193-17

5

Hui Pang, Kanglin Wan, Lin Wei* Single-nucleotide polymorphisms related to fluoroquinolone and aminoglycoside resistance in Mycobacterium avium isolates.  Infection and Drug Resistance 2018:11 515–521

6

Jiayang Jin, Zhaofei Jing, Zhenjie Ye , Lu Guo, Lei Hua, Qingyang Wang, Jing Wang, Qianqian Cheng, Jiyan Zhang, Yunlu Xu and Lin Wei* MLN4924 suppresses lipopolysaccharideinduced proinflammatory cytokine production in neutrophils in a dosedependent manner.  Oncology  Letters 2018 , 15: 8039-8045

7

Lei ZhangHongyong LiYan HaiWei YinWenjian LiBoyang ZhengXiaomin DuNa LiZhengzheng ZhangYuqing DengRuihong Zeng*Lin Wei* CpG in combination with an inhibitor of Notch signalingsuppresses FI-RSV-enhanced airway hyperresponsiveness andinflammation through inhibitingTh17 memory responses in lungs. J Virol. 2017, 91(10): e02111-16.

8

Song, Xiaotian#Yao, Zhiyan#Yang, JianlingZhang, ZhengzhengDeng, YuqingLi, MiaoMa, CuiqingYang, LijuanGao, XueLi, WenjianLiu, JianguoWei, Lin* HCV core protein binds to gC1qR to induce A20 expression and inhibit cytokine production through MAPKs and NF-kappa B signaling pathwaysOncotarget2016. 723):33796~33808

9

Shuhui Wu#, Cuiqing Ma#, Xue Gao, Ling Zhang, Qingfeng Miao, Miao Li, Wenjian Li, Xiaotian Song, Xiurong Wang, Jianguo Liu, Lin Wei* Group A Streptococcus induces less p65 nuclear translocation and non-classical nuclear factor kappa B activation in macrophages, which possibly leads to a weaker inflammatory response . IJID, 2016, 44: 50–60

10

Shi, Xin-liYang, JingMao, NanWu, Jing-huaRen, Lai-fengYang,YuanYin, Xiao-linWei, Lin*Li, Ming-yuanWang, Bao-Ning  Nutlin-3-induced redistribution of chromatin-bound IFI16 in human hepatocellular carcinoma cells in vitro is associated with p53 activationActa Pharmacologica Sinica2015.2.01362):252~258

11

Wu Jinghua, Ma Cuiqing, Wang Haixin, Wu Shuhui, Gao Xue, Shi Xinli, Song Zhang, Wei Lin*. A MyD88-JAK1-STAT1 complex directly induces SOCS-1 expression in macrophages infected with Group A Streptococcus. Cellular & Molecular Immunology  2014 Nov 17. doi: 10.1038/cmi.2014.107

12

Cuiqing Ma, Zheng Liu, Wenjian Li, Xuesong Qian, Song Zhang, Xue Gao, Shibo Jiang, Lin Wei*. FbaA- and M protein-based multi-epitope vaccine elicits strong protective immune responses against group A streptococcus in mouse model. Microbes and infection, 2014;16 (5): 409-418

13

Yao Z, Song X, Cao S, Liang W, Lu W, Yang L, Zhang Z, Lin Wei* Role of the Exogenous HCV Core Protein in the Interaction of Human Hepatocyte Proliferation and Macrophage Sub-Populations. PloS one 2014, 9(9):e108278.

14

Song, ShuxiaWang, YueWang, JunxiaLian, WeiguangLiu, ShufengZhang, ZhengzhengLiu, Fuying*, Wei, Lin* . Tumour-derived IL-10 within tumour microenvironment represses the antitumour immunity of Socs1-silenced and sustained antigen expressing DCsEuropean Journal of Cancer2012.9.014814):2252~2259

15

Ma C, Guo Y, Gu H, Zhang L, Liu H, Feng H, and Lin Wei* A Novel Monoclonal Antibody against FbaA Can Inhibit the Binding of the Complement Regulatory Protein Factor H to Group A Streptococcus. Clinical and Vaccine Immunology, 2011, 18(4): 552-558

16

Ma, CuiqingGuo, YiyangGu, HaiyanZhang, LingLiu, HainanFeng, HuidongWei, Lin *A Novel Monoclonal Antibody against FbaA Can Inhibit the Binding of the Complement Regulatory Protein Factor H to Group A Streptococcus Clinical and Vaccine Immunology2011.4.01184):552~558

17

Yin, XiaolinHou, TianwenLiu, YingChen, JingYao, ZhiyanMa,CuiqingYang, LijuanWei, Lin *Association of Toll-Like Receptor 4 Gene Polymorphism and Expression with Urinary Tract Infection Types in AdultsPLos One2010.12.3512

18

Yin, XiaolinChen, LeiLiu, YingYang, JianlingMa, CuiqingYao,ZhiyanYang, LijuanWei, Lin* Li, Mingyuan *Enhancement of the innate immune response of bladder epithelial cells by Astragalus polysaccharides through upregulation of TLR4 expressionBiochemical and Biophysical Research Communications2010.6.253972):232~238

19

Zeng, Ruihong Li, GuangxueLing, ShiganZhang, HeqiuYao, ZhiyanXiu, BingshuiHe, FengHuang, RuiWei, Lin* A novel combined vaccine candidate containing epitopes of HCV NS3, core and E1 proteins induces multi-specific immune responses in BALB/c miceAntiviral Research2009.10.01 841):23~30

20

Ma, CuiqingLi, CaihongWang, XiurongZeng, RuihongYin, XiaolinFeng, HuidongWei, Lin *Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in MiceCellular and Molecular Immunology2009.2.0161):73~77

21

Yin, Xiao-LinHou, Tian-WenXu, Shu-BinMa, Cui-QingYao, Zhi-YanLi, WeiWei, Lin *  Detection of drug resistance-associated genes of multidrug-resistant Acinetobacter baumanniiMicrobial Drug Resistance2008.6. 01142):145~150

22

Lin Wei, Vinod Pandiripally, Eugene Gregory, Micaya Clymer, and David Cue* Impact of the SpeB Protease on Binding of the Complement Regulatory Proteins Factor H and Factor H-Like Protein 1 by Streptococcus pyogenes.  Infection and Immunity, Apr. 2005, p. 2040–2050

23

Qinghong Wang, Huan Ning, Hui Peng, Lin Wei, Rong Hou, Daniel F. Hoft and Jianguo Liu. Tristetraprolin inhibits macrophage IL-27-induced activation of antitumour cytotoxic T cell responses. Nature Communications 2017; 11; 8(1):867

24

Li Xu, Huan Ning, Ling Gu, Qinghong Wang, Wenbao Lu, Hui Peng, Weiguang Cui, Baoling Ying, Christina Ross, Gerald Wilson, Lin Wei, William Wold and Jianguo Liu. Tristetraprolin induces cell cycle arrest in breast tumor cells through targeting AP-1/c-Jun and NF-κB pathway. Oncotarget 2015; 8; 6(39): 41679-91.

25

Xuesong Qian,,  Ling Gu,  Huan Ning,, Yanping Zhang,  Eddy C. Hsueh, Xiaoyu Hu,  Lin Wei,  Daniel F. Hoft,  and Jianguo Liu, Tumor-Secreted Prostaglandin E2 Microenvironment Is Mediated by IL-23 via Increased Th17 Cells in the Tumor  J Immunol 2013, May 3, doi:10.4049/jimmunol.1203141

26

Zeng, Ruihong Zhang, HuixianHai, YanCui, YuxiuLi, Wei, Lin, NaLiu, JianxunLi, CaixiaLiu, YingInterleukin-27 Inhibits Vaccine-Enhanced Pulmonary Disease following Respiratory Syncytial Virus Infection by Regulating Cellular Memory ResponsesJournal of Virology2012.4.01868):4505~4517

27

Zeng, Ruihong Li, CaixiaLi, NaCui, YuXiuWei, Lin . The role of cytokines and chemokines in severe respiratory syncytial virus infection and subsequent asthmaCytokine2011.1.01531):1~7

28

Zeng, Ruihong Zhang, ZhenyaMei, XingguoGong, Wei, Wei, Lin  Protective effect of a RSV subunit vaccine candidate G1F/M2 was enhanced by a HSP70-Like protein in miceBiochemical and Biophysical Research Communications 2008.12.123772):495~499

29

Zeng, Ruihong Qi, XiaowenGong, WeiMei, Xingguo, Wei, Lin, Ma, CuiqingYin, XiaolinLong-lasting balanced immunity and protective efficacy against respiratory syncytial virus in mice induced by a recombinant protein G1F/M2Vaccine2007.10.162542):7422~74

30

Vinod Pandiripally, Lin Wei, Christine Skerka,2 Peter F. Zipfel,2 and David Cue1* Recruitment of Complement Factor H-Like Protein 1 Promotes Intracellular Invasion by Group A Streptococci Infect. & immun. 2005, 71(12):7119–7128

 

 

四、团队现有承担课题情况

(一)国家自然科学基金面上项目,31770971呼吸道合胞病毒(RSV)利用线粒体自噬增强自身复制的作用研究 2018/01-2021/12,60万、在研、主持人:魏林。

(二)国家自然科学基金面上项目,31370914、 A族链球菌作用巨噬细胞通过TLR4/MYD88途径诱导SOCS-1而发生早期免疫逃逸的机制研究 2014/1-2017/12, 70万、已结题主持人:魏林

(三)国家自然科学基金面上项目,81172810A族链球菌酶活性蛋白下调巨噬细胞细胞因子产生的作用及机制2012/01-2012/12,8万、已结题、主持人:魏林

(四)国家自然科学基金面上项目30872399、A族链球菌Fba蛋白抗原表位的鉴定及其作用机制的研究、2009/01-2011/12, 33万元、已结题、主持人:魏林

(五)国家自然科学基金面上项目,30771970、Fba蛋白在A族链球菌逃避补体攻击中的作用机制、2008/1-2008/12, 8万,已结题、主持人:魏林

(六)整合素α5β1是病原菌结合Fn启动细胞自噬的通用受体(81971474),研究期限:2020.01-2023.12,53万。在研、主持人: 马翠卿

(七)A族链球菌诱导巨噬细胞 IL-6 下调以逃避免疫攻击的机制研究(30901350),研究期限:2010.01 至 2012.12,18万。结题、主持人: 马翠卿

(八)国家自然基金青年基金项目,81701994,新发现的长链非编码RNA lnc-BOLA3-4对HBV复制调控的功能验证与机制研究,2018/1-2020/12,20万元,在研,主持人:揣侠。

(九)呼吸道合胞病毒(RSV)NS1蛋白利用自噬机制抑制细胞Ⅰ型干扰素应答的作用研究,国家自然科学基金青年基金,21万,课题号:81802014,2019.1-2021.12,在研,主持人:李苗。

 

 

五、团队人员

第一组


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马翠卿免疫学博士、教授,硕士生导师,免疫学课程负责人,河北重大疾病免疫机制及干预重点实验室副主任, 2012-2014年于美国血液中心做博士后研究,主要从事感染免疫及干细胞治疗的研究。先后主持多项国家自然科学基金、教育部科学技术研究重点项目、河北省高层次人才资助项目、河北省自然科学基金等课题。目前兼任中华医学会微生物免疫分会青年委员,河北医学会微生物免疫分会后任主委;河北省免疫学会教育分会副主委,河北省微生物学会理事河北省科技厅项目评审及科技奖励评审专家。发表论文30余篇,其中以第一作者发表SCI论文11篇,培养研究生10余名,目前在读研究生4名。主讲《医学免疫学》课程21年,具有丰富的教学经验,参编国家统编教材3部;先后获得河北省教育厅第六届教学软件大赛二等奖、mg游戏平台电子手机版下载青年教师授课大赛三等奖、基础医学院青年教师授课大赛一等奖。

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李苗,女,医学博士,副教授,从事医学免疫学教学和科研工作。主要研究方向是探讨病毒逃逸宿主固有免疫应答机制、细胞自噬在病毒感染中的作用等。主持国家自然科学基金青年基金1项,河北省教育厅高等学校科学技术研究项目1项,参与国家自然科学基金及其他省级课题多项。任河北省微生物学会理事、河北省医学会微生物及免疫分会委员兼秘书。

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李剑,博士,讲师。主要从事呼吸道合胞病毒致病机制研究、疫苗研究,发表学术论文13篇,其中,其中SCI论文2篇。参与国家自然基金项目3项。

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高雪,医学硕士,中级,实验师。主要从事感染免疫机制方向研究工作,参与国家自然科学基金项目、河北省自然科学基金项目、河北省高等学校科学技术研究项目等多项课题研究。主持河北省高等教育科学研究规划课题一项、mg游戏平台电子手机版下载教育教学研究课题一项,并发表论文

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王家超,医学博士,助教。主要从事细胞自噬与细菌感染的相互作用研究。参与国家自然科学基金项目、河北省自然科学基金项目、河北省高等学校科学技术研究项目等多项课题研究。以第一作者在mBio发表论文一篇。



第二组

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揣侠,女,博士,教授,硕士生导师,2013年毕业于中国疾病预防控制中心并获得博士学位。主要从事乙肝病毒等致病机制、疫苗及药物等方面的研究,目前发表学术论文20余篇,其中第一作者或共同第一作者文章15篇,含SCI论文7篇,影响因子达20余分。承担国家自然基金青年基金一项,河北省教育厅重点课题一项,结题完成河北省自然科学基金一项,并参与多项国家级及省级课题。社会兼职:中国医药教育协会微生态与健康教育专业会委员;中华医学会医学病毒学分会第八届委员会青年委员;河北省预防医学会医学寄生虫专业委员会常委;河北省医学会微生物与免疫学分会第五届委员会委员;河北省预防医学会疫苗与健康专业委员会副主任委员;河北省微生物学会理事;河北省急救医学会感染病专业委员会委员。

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王卫杰,博士,副教授,主要从事病原生物学相关科研工作。主持并完成河北省高等学校科学技术研究项目1项,参与国家自然科学基金、河北省自然科学基金、河北省高等学校科学技术研究项目、医学科学研究课题多项,发表SCI论文17篇(其中第一作者2篇),核心期刊10余篇(第一作者或通讯作者5篇)。担任河北省预防医学会医学寄生虫学专业委员会委员,河北省临床肿瘤学会肿瘤转化医学专业委员会委员,河北省数理医学学会青年委员会委员。

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高志云,博士,副教授,毕业于中国疾病预防控制中心,主要从事HIV新发感染检测及柯萨奇病毒致病机制、疫苗研究,累计发表文章20余篇,现主持河北省教育厅课题1项,参与河北省自然科学基金、教育厅课题4项。

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赵艳,医学博士,副教授。主要研究方向为分子病毒学,目前从事乙肝病毒相关致病机制、药物等方面的研究。累计发表学术论文9篇,其中SCI论文7篇。参与国自然基金项目一项。

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乔红秀,医学硕士,中级实验师。从事病毒学相关科研工作和实验室管理。


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