1 | Zhang F, Wang Y, Liu Y, Han H, Zhang D, Fan X, Du X, Gamper N, Zhang H. Transcriptional Regulation of Voltage-Gated Sodium Channels Contributes to GM-CSF-Induced Pain. J Neurosci. 2019 Jun 26;39(26):5222-5233. |
2 | Li L, Sun H, Ding J, Niu C, Su M, Zhang L, Li Y, Wang C, Gamper N, Du X, Zhang H. Selective targeting of M-type potassium Kv 7.4 channels demonstrates their key role in the regulation of dopaminergic neuronal excitability and depression-like behaviour. Br J Pharmacol. 2017 Dec;174(23):4277-4294. |
3 | Zhang X, An H，Li J, Zhang Y, Liu Y, Jia Z, Zhang W, Chu L and Zhang H. Selective activation of vascular Kv 7.4/Kv 7.5 K+ channels by fasudil contributes to its vasorelaxant effect. Br J Pharmacol，2016.12.01;173(24)：3480~3491 |
4 | Du X*, Hao H, Yang Y, Huang S, Wang C, Gigout S, Ramli R, Li X, Jaworska E, Edwards I, Deuchars J, Yanagawa Y, Qi J, Guan B, Jaffe DB, Zhang H*, Gamper N*. Local GABAergic signaling within sensory ganglia controls peripheral nociceptive transmission. J Clin Invest. 2017 May 1;127(5):1741-1756. |
5 | Huang D, Huang S，Gao H，Liu Y，Qi J，Chen P，Wang C，Scragg JL.，Vakurov A，Peers C，Du X，Gamper N, Zhang H. Redox-Dependent Modulation of T-Type Ca2+ Channels in Sensory Neurons Contributes to Acute Anti-Nociceptive Effect of Substance P. Antioxidants & Redox Signaling，2016.8.01;25(5)：233~251 |
6 | Zhou N, Huang S，Li L，Huang D，Yan Y，Du X and Zhang H. K(v)7/kcnq potassium channel enhances neuronal differentiation of pc12 cells，Neuroscience，2016.10.1，333：356~367 |
7 | Xu J，Si M，Zhang H，Chen X，Zhang X，Wang C，Du X， Zhang H. Phosphoinositide Kinases Play Key Roles in Norepinephrine- and Angiotensin II-induced Increase in Phosphatidylinositol 4,5-Bisphosphate and Modulation of Cardiac Function，Journal of Biological Chemistry，2014.3.7，289(10)：6941~6948 |
8 | Zhang X, Du XN, Zhang GH, Jia ZF, Chen XJ, Huang DY, Liu BY, Zhang HL Agonist-dependent Potentiation of Vanilloid Receptor TRPV1 Function by Stilbene Derivatives. Mol Pharmacol. 2012 81:689–700 |
9 | Chen X, Zhang X, Jia C, Xu J, Gao H, Zhang G, Du X, Zhang H. Membrane Depolarization Increases Membrane PtdIns(4,5)P2 Levels through Mechanisms Involving PKCβII and PI4 Kinase. J Biol Chem. 2011 Sep, 286(46), 39760-39767 |
10 | Gao H, Chen X, Du X, Guan B, Liu Y, Zhang H. EGF enhances the migration of cancer cells by up-regulation of TRPM7. Cell Calcium. 2011 Oct 4. 50(6),559-568 |
11 | Du X, Zhang X, Qi J, An H, Li J, Wan Y, Fu Y, Gao H, Gao Z, Zhan Y, Zhang H. Characteristics and molecular basis of celecoxib modulation on Kv7 potassium channels. Br J Pharmacol. 2011 May 13.164(6),1722-1737 |
12 | Liu B, Linley JE, Du X, Zhang X, Ooi L, Hailin Zhang H*, Gamper N* (2010). The acute nociceptive signals induced by bradykinin in rat sensory neurons are mediated by inhibition of M-type K+ channels and activation of Ca2+-activated Cl– channels. J Clin Invest 120 (4):1240-1252 |
13 | Qi J, Zhang F, Mi Y, Fu Y, Xu W, Zhang D, Wu Y, Du X, Jia Q, Wang K, Zhang H. Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. Eur J Med Chem. 2011 Mar;46(3):934-43. Epub 2011 Jan 22. |
14 | Zhang X, Chen X, Jia C, Geng X, Du X, and Zhang H(2010). Depolarization Increases Phosphatidylinositol (PI)4,5-Bisphosphate Level and KCNQ Currents through PI4-Kinase Mechanisms. J Biol Chem. 285, 9402–9409 |
15 | Liu B, Zhang X, Wang C, Zhang G, Zhang H. Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons. Neuropharmacology. 2008 Mar;54(4):629-39 |
16 | Wang C, Mirshahi UL, Liu B, Jia Z, Mirshahi M, and Zhang H（2008）Arachidonic Acid Activates Kir2.3 Channels by Enhancing Channel–Phosphatidyl-inositol 4,5-bisphosphate Interactions. Mol Pharmacol 73:1185–1194 |
17 | Jia Z, Bei J, Rodat-Despoix L, Liu B, Jia Q, Delmas P, Zhang H. NGF inhibits M/KCNQ currents and selectively alters neuronal excitability in subsets of sympathetic neurons depending on their M/KCNQ current background. J Gen Physiol. 2008 Jun;131(6):575-87. |
18 | Jia Q, Jia Z, Zhao Z, Liu B, Liang H and Zhang H（2007） Activation of EGF receptor inhibits KCNQ2/3 current through two distinct pathways: membrane PtdIns(4,5)P2 hydrolysis and channel phosphorylation. J. Neurosci. 27(10):2503–2512 |
19 | Zhang H., Craciun LC, Mirshahi T, Rohács T, Lopes CMB, Jin T, and Logothetis DE. (2003) PIP2 Activates KCNQ Channels, and Its Hydrolysis Underlies Receptor-Mediated Inhibition of M Currents. Neuron 37（6）, 963-975 |
20 | Zhang H, He C., Yan XX, Mirshahi T and Logothetis DE. (1999) Activation of inwardly rectifying K+ channels by distinct PtdIns(4,5)P2 interactions. Nature Cell Biology, 1:183-188 |
张海林教授，博士生导师，mg游戏平台电子手机版下载副校长、医学与健康研究院院长。燕赵学者，国家杰出青年科学基金获得者，享受国务院政府特殊津贴，获中国侨联科技创新人才奖，河北省十大科技杰出青年，河北省强势学科（药理学）带头人，中国侨联特聘专家，省管优秀专家。中国神经科学学会常务理事；河北省神经科学学会理事长，河北省药理学会理事长。英国伦敦大学圣乔治医学院博士、英国伦敦大学博士后、美国纽约大学西奈山医学中心博士后，并任教职，2013年归国。近年来主持国家“973”项目课题、国家自然基金重点项目、面上项目、科技部重大基础研究前期研究专项等，在国际高水平学术杂志Nat. Cell Biol., Neuron、J. Clin. Invest., J. Neurosci.等发表SCI 论文80多篇，任J. Gen. Physiol., Channels等国际著名SCI期刊编委，授权国内外专利近10项。